01 - In a large bowl, whisk together buttermilk and hot sauce. Add chicken pieces, coating well. Cover and refrigerate for at least 4 hours or overnight.
02 - In a large bowl, combine flour, baking powder, baking soda, sugar, and salt. Cut in cold butter with a pastry cutter or fork until mixture resembles coarse crumbs. Add cold buttermilk and mix just until dough comes together. Turn onto a floured surface, gently pat to 3/4-inch thickness. Fold dough in half and pat out again; repeat twice for flakiness.
03 - Cut biscuits with a 2-inch cutter. Place on parchment-lined baking sheet, close together for soft sides. Brush tops with buttermilk. Bake at 425°F for 12–15 minutes or until golden brown. Cool slightly before serving.
04 - In a shallow dish, mix flour, paprika, garlic powder, onion powder, salt, black pepper, and cayenne. Remove chicken from marinade, allowing excess to drip off. Dredge each piece in seasoned flour, pressing to adhere. Let coated chicken rest for 10 minutes.
05 - Heat 1–2 inches of vegetable oil in a large, heavy skillet to 350°F. Fry chicken in batches, turning occasionally, until golden brown and cooked through (about 15–18 minutes for dark meat, 12–15 minutes for white meat). Drain on rack or paper towels.
06 - Enjoy hot fried chicken with warm, flaky biscuits.