01 - In a large skillet over medium-high heat, cook the ground beef with salt, pepper, smoked paprika, and garlic powder. Break up the meat and stir occasionally until browned and cooked through, about 7-8 minutes. Drain excess fat if needed.
02 - While the beef is cooking, whisk together the mayonnaise, ketchup, mustard, pickle relish, vinegar, smoked paprika, salt, and pepper in a small bowl. Set aside.
03 - Divide the chopped romaine lettuce equally among four large serving bowls.
04 - Top each bowl with equal portions of cooked ground beef, cherry tomatoes, cheddar cheese, red onion, pickle slices, and diced avocado.
05 - Drizzle each bowl with burger sauce just before serving. Serve immediately.